diff --git a/boring-sys/Cargo.toml b/boring-sys/Cargo.toml
index 15e6025e..34e8df21 100644
--- a/boring-sys/Cargo.toml
+++ b/boring-sys/Cargo.toml
@@ -57,6 +57,10 @@ fips = []
 # `BORING_BSSL{,_FIPS}_SOURCE_PATH`.
 underscore-wildcards = []
 
+# Add a prefix to all symbols in libcrypto and libssl to prevent conflicts
+# with other OpenSSL or BoringSSL versions that might be linked in the same process.
+prefix-symbols = []
+
 [build-dependencies]
 bindgen = { workspace = true }
 cmake = { workspace = true }
diff --git a/boring-sys/build/config.rs b/boring-sys/build/config.rs
index 25aaabf4..a8aaed62 100644
--- a/boring-sys/build/config.rs
+++ b/boring-sys/build/config.rs
@@ -18,6 +18,7 @@ pub(crate) struct Features {
     pub(crate) fips: bool,
     pub(crate) rpk: bool,
     pub(crate) underscore_wildcards: bool,
+    pub(crate) prefix_symbols: bool,
 }
 
 pub(crate) struct Env {
@@ -105,11 +106,13 @@ impl Features {
         let fips = env::var_os("CARGO_FEATURE_FIPS").is_some();
         let rpk = env::var_os("CARGO_FEATURE_RPK").is_some();
         let underscore_wildcards = env::var_os("CARGO_FEATURE_UNDERSCORE_WILDCARDS").is_some();
+        let prefix_symbols = env::var_os("CARGO_FEATURE_PREFIX_SYMBOLS").is_some();
 
         Self {
             fips,
             rpk,
             underscore_wildcards,
+            prefix_symbols,
         }
     }
 
diff --git a/boring-sys/build/main.rs b/boring-sys/build/main.rs
index c995a580..76bb6bec 100644
--- a/boring-sys/build/main.rs
+++ b/boring-sys/build/main.rs
@@ -9,8 +9,10 @@ use std::process::{Command, Output};
 use std::sync::OnceLock;
 
 use crate::config::Config;
+use crate::prefix::{prefix_symbols, PrefixCallback};
 
 mod config;
+mod prefix;
 
 fn should_use_cmake_cross_compilation(config: &Config) -> bool {
     if config.host == config.target {
@@ -544,6 +546,10 @@ fn built_boring_source_path(config: &Config) -> &PathBuf {
                 .define("FIPS", "1");
         }
 
+        if config.features.prefix_symbols {
+            cfg.define("CMAKE_POSITION_INDEPENDENT_CODE", "ON");
+        }
+
         cfg.build_target("ssl").build();
         cfg.build_target("crypto").build()
     })
@@ -571,6 +577,9 @@ fn main() {
     if !config.env.docs_rs {
         emit_link_directives(&config);
     }
+    if config.features.prefix_symbols {
+        prefix_symbols(&config);
+    }
     generate_bindings(&config);
 }
 
@@ -665,6 +674,10 @@ fn generate_bindings(config: &Config) {
             .clang_arg(sysroot.display().to_string());
     }
 
+    if config.features.prefix_symbols {
+        builder = builder.parse_callbacks(Box::new(PrefixCallback));
+    }
+
     let headers = [
         "aes.h",
         "asn1_mac.h",
diff --git a/boring-sys/build/prefix.rs b/boring-sys/build/prefix.rs
new file mode 100644
index 00000000..01dd8510
--- /dev/null
+++ b/boring-sys/build/prefix.rs
@@ -0,0 +1,81 @@
+use crate::{config::Config, pick_best_android_ndk_toolchain, run_command};
+use std::{fs, io::Write, path::PathBuf, process::Command};
+// The prefix to add to all symbols
+// RBSSL = Rust BoringSSL, chosen arbitrarily to avoid collisions with other projects
+const PREFIX: &str = "RBSSL";
+// Callback to add a `link_name` macro with the prefix to all generated bindings
+#[derive(Debug)]
+pub struct PrefixCallback;
+impl bindgen::callbacks::ParseCallbacks for PrefixCallback {
+    fn generated_link_name_override(
+        &self,
+        item_info: bindgen::callbacks::ItemInfo<'_>,
+    ) -> Option<String> {
+        Some(format!("{PREFIX}_{}", item_info.name))
+    }
+}
+fn android_toolchain(config: &Config) -> PathBuf {
+    let mut android_bin_path = config
+        .env
+        .android_ndk_home
+        .clone()
+        .expect("Please set ANDROID_NDK_HOME for Android build");
+    android_bin_path.extend(["toolchains", "llvm", "prebuilt"]);
+    android_bin_path.push(pick_best_android_ndk_toolchain(&android_bin_path).unwrap());
+    android_bin_path.push("bin");
+    android_bin_path
+}
+pub fn prefix_symbols(config: &Config) {
+    // List static libraries to prefix symbols in
+    let static_libs: Vec<PathBuf> = [
+        config.out_dir.join("build"),
+        config.out_dir.join("build").join("ssl"),
+        config.out_dir.join("build").join("crypto"),
+    ]
+    .iter()
+    .flat_map(|dir| {
+        ["libssl.a", "libcrypto.a"]
+            .into_iter()
+            .map(move |file| PathBuf::from(dir).join(file))
+    })
+    .filter(|p| p.exists())
+    .collect();
+    // Use `nm` to list symbols in these static libraries
+    let nm = match &*config.target_os {
+        "android" => android_toolchain(config).join("llvm-nm"),
+        _ => PathBuf::from("nm"),
+    };
+    let out = run_command(Command::new(nm).args(&static_libs)).unwrap();
+    let mut redefine_syms: Vec<String> = String::from_utf8_lossy(&out.stdout)
+        .lines()
+        .filter(|l| {
+            [" T ", " D ", " B ", " C ", " R ", " W "]
+                .iter()
+                .any(|s| l.contains(s))
+        })
+        .filter_map(|l| l.split_whitespace().nth(2).map(|s| s.to_string()))
+        .filter(|l| !l.starts_with("_"))
+        .map(|l| format!("{l} {PREFIX}_{l}"))
+        .collect();
+    redefine_syms.sort();
+    redefine_syms.dedup();
+    let redefine_syms_path = config.out_dir.join("redefine_syms.txt");
+    let mut f = fs::File::create(&redefine_syms_path).unwrap();
+    for sym in &redefine_syms {
+        writeln!(f, "{sym}").unwrap();
+    }
+    f.flush().unwrap();
+    // Use `objcopy` to prefix symbols in these static libraries
+    let objcopy = match &*config.target_os {
+        "android" => android_toolchain(config).join("llvm-objcopy"),
+        _ => PathBuf::from("objcopy"),
+    };
+    for static_lib in &static_libs {
+        run_command(
+            Command::new(&objcopy)
+                .arg(format!("--redefine-syms={}", redefine_syms_path.display()))
+                .arg(static_lib),
+        )
+        .unwrap();
+    }
+}
diff --git a/boring/Cargo.toml b/boring/Cargo.toml
index 227ff998..51dd8ec8 100644
--- a/boring/Cargo.toml
+++ b/boring/Cargo.toml
@@ -32,6 +32,10 @@ legacy-compat-deprecated = []
 # `BORING_BSSL{,_FIPS}_ASSUME_PATCHED`.
 underscore-wildcards = ["boring-sys/underscore-wildcards"]
 
+# Add a prefix to all symbols in libcrypto and libssl to prevent conflicts
+# with other OpenSSL or BoringSSL versions that might be linked in the same process.
+prefix-symbols = ["boring-sys/prefix-symbols"]
+
 [dependencies]
 bitflags = { workspace = true }
 foreign-types = { workspace = true }