diff --git a/boring-sys/build/config.rs b/boring-sys/build/config.rs
index 588ec8d6..12e89ffa 100644
--- a/boring-sys/build/config.rs
+++ b/boring-sys/build/config.rs
@@ -27,6 +27,8 @@ pub(crate) struct Env {
     pub(crate) source_path: Option<PathBuf>,
     pub(crate) precompiled_bcm_o: Option<PathBuf>,
     pub(crate) assume_patched: bool,
+    pub(crate) sysroot: Option<PathBuf>,
+    pub(crate) compiler_external_toolchain: Option<PathBuf>,
     pub(crate) debug: Option<OsString>,
     pub(crate) opt_level: Option<OsString>,
     pub(crate) android_ndk_home: Option<PathBuf>,
@@ -145,6 +147,9 @@ impl Env {
             precompiled_bcm_o: boringssl_var("BORING_BSSL_PRECOMPILED_BCM_O").map(PathBuf::from),
             assume_patched: boringssl_var("BORING_BSSL_ASSUME_PATCHED")
                 .is_some_and(|v| !v.is_empty()),
+            sysroot: boringssl_var("BORING_BSSL_SYSROOT").map(PathBuf::from),
+            compiler_external_toolchain: boringssl_var("BORING_BSSL_COMPILER_EXTERNAL_TOOLCHAIN")
+                .map(PathBuf::from),
             debug: target_var("DEBUG"),
             opt_level: target_var("OPT_LEVEL"),
             android_ndk_home: target_var("ANDROID_NDK_HOME").map(Into::into),
diff --git a/boring-sys/build/main.rs b/boring-sys/build/main.rs
index 9adf9a45..8ddf7ff1 100644
--- a/boring-sys/build/main.rs
+++ b/boring-sys/build/main.rs
@@ -193,6 +193,23 @@ fn get_boringssl_cmake_config(config: &Config) -> cmake::Config {
         return boringssl_cmake;
     }
 
+    boringssl_cmake
+        .define("CMAKE_CROSSCOMPILING", "true")
+        .define("CMAKE_C_COMPILER_TARGET", &config.target)
+        .define("CMAKE_CXX_COMPILER_TARGET", &config.target)
+        .define("CMAKE_ASM_COMPILER_TARGET", &config.target);
+
+    if let Some(sysroot) = &config.env.sysroot {
+        boringssl_cmake.define("CMAKE_SYSROOT", sysroot);
+    }
+
+    if let Some(toolchain) = &config.env.compiler_external_toolchain {
+        boringssl_cmake
+            .define("CMAKE_C_COMPILER_EXTERNAL_TOOLCHAIN", toolchain)
+            .define("CMAKE_CXX_COMPILER_EXTERNAL_TOOLCHAIN", toolchain)
+            .define("CMAKE_ASM_COMPILER_EXTERNAL_TOOLCHAIN", toolchain);
+    }
+
     // Add platform-specific parameters for cross-compilation.
     match &*config.target_os {
         "android" => {
@@ -647,6 +664,12 @@ fn main() {
         .clang_arg("-I")
         .clang_arg(include_path.display().to_string());
 
+    if let Some(sysroot) = &config.env.sysroot {
+        builder = builder
+            .clang_arg("--sysroot")
+            .clang_arg(&sysroot.display().to_string());
+    }
+
     match &*config.target {
         // bindgen produces alignment tests that cause undefined behavior [1]
         // when applied to explicitly unaligned types like OSUnalignedU64.