diff --git a/.circleci/config.yml b/.circleci/config.yml
index a7fd91b4..58509952 100644
--- a/.circleci/config.yml
+++ b/.circleci/config.yml
@@ -109,6 +109,9 @@ libressl_250: &LIBRESSL_250
 libressl_270: &LIBRESSL_280
   LIBRARY: libressl
   VERSION: 2.8.0
+libressl_281: &LIBRESSL_281
+  LIBRARY: libressl
+  VERSION: 2.8.1
 
 x86_64: &X86_64
   TARGET: x86_64-unknown-linux-gnu
@@ -197,6 +200,10 @@ jobs:
     <<: *JOB
     environment:
       <<: [*LIBRESSL_280, *X86_64, *BASE]
+  x86_64-libressl-2.8.1:
+    <<: *JOB
+    environment:
+      <<: [*LIBRESSL_281, *X86_64, *BASE]
   macos:
     <<: *MACOS_JOB
     environment:
@@ -225,5 +232,6 @@ workflows:
     - armhf-openssl-1.0.2
     - x86_64-libressl-2.5.0
     - x86_64-libressl-2.8.0
+    - x86_64-libressl-2.8.1
     - macos
     - macos-vendored
diff --git a/openssl-sys/build/cfgs.rs b/openssl-sys/build/cfgs.rs
index cfd85cbb..e07be8cf 100644
--- a/openssl-sys/build/cfgs.rs
+++ b/openssl-sys/build/cfgs.rs
@@ -19,6 +19,9 @@ pub fn get(openssl_version: Option<u64>, libressl_version: Option<u64>) -> Vec<&
         if libressl_version >= 0x2_08_00_00_0 {
             cfgs.push("libressl280");
         }
+        if libressl_version >= 0x2_08_01_00_0 {
+            cfgs.push("libressl281");
+        }
     } else {
         let openssl_version = openssl_version.unwrap();
 
diff --git a/openssl-sys/build/main.rs b/openssl-sys/build/main.rs
index 4c615401..062ba21e 100644
--- a/openssl-sys/build/main.rs
+++ b/openssl-sys/build/main.rs
@@ -497,7 +497,8 @@ See rust-openssl README for more information:
             (6, 2) => ('6', '2'),
             (6, _) => ('6', 'x'),
             (7, _) => ('7', 'x'),
-            (8, 0) => ('8', 'x'),
+            (8, 0) => ('8', '0'),
+            (8, 1) => ('8', '1'),
             _ => version_error(),
         };
 
@@ -538,7 +539,7 @@ fn version_error() -> ! {
         "
 
 This crate is only compatible with OpenSSL 1.0.1 through 1.1.1, or LibreSSL 2.5
-through 2.7, but a different version of OpenSSL was found. The build is now aborting
+through 2.8.1, but a different version of OpenSSL was found. The build is now aborting
 due to this version mismatch.
 
 "
diff --git a/openssl-sys/src/ocsp.rs b/openssl-sys/src/ocsp.rs
index 19247ce2..82157f32 100644
--- a/openssl-sys/src/ocsp.rs
+++ b/openssl-sys/src/ocsp.rs
@@ -45,7 +45,7 @@ pub const V_OCSP_CERTSTATUS_UNKNOWN: c_int = 2;
 pub enum OCSP_BASICRESP {}
 
 cfg_if! {
-    if #[cfg(ossl110)] {
+    if #[cfg(any(ossl110, libressl281))] {
         extern "C" {
             pub fn OCSP_cert_to_id(
                 dgst: *const EVP_MD,